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Illicit compounds, counterfeit and unregistered weight-loss medicines: know the risks

Some medicines sold online, through social media, or by informal sellers may not be what they claim to be. They may be counterfeit, falsified, substandard or unregistered — and this can put your health at risk.

This page explains how to spot warning signs, why prescription medicines should only be used with proper medical guidance, and what to do if you are worried about a medicine, you have bought or been offered.

Buying medicine online


If you are unsure, do not use the medicine. Speak to a doctor or pharmacist first.

South African Health Products Regulatory Authority (SAHPRA) advises the public to use legitimate products only: in original packaging, from licensed manufacturers, prescribed by registered healthcare professionals and dispensed by licensed pharmacists. It also warns that products from social media, online vendors, gyms or informal suppliers are likely to be counterfeit or substandard.

Why this matters now

South African regulators have warned the public about unregistered GLP‑1 and GIP medicines being promoted for weight loss. SAHPRA and the South African Pharmacy Council have taken enforcement action against unlawful manufacturing and distribution of these products.

These actions are helping people make safer choices and avoid products that may not have been properly registered, manufactured, stored or supplied.

The court ruled in favour of Novo Nordisk South Africa and granting our interim interdict application. iDexis was found to be illegally compounding semaglutide as the Judge ruled that only registered  APIs (active pharmaceutical ingredient) can be used in a compound, on presentation of a prescription from a doctor. The court noted that iDexis was sourcing and using an untested API that was not registered or sourced from the original registered supplier.

NOVO NORDISK PRESS RELEASE

What do these words mean?

Compounded medicine

Compounding is when a pharmacy prepares a medicine for a specific patient in specific circumstances, based on a valid prescription. Compounded medicine is not the same as mass manufacturing. SAHPRA has stated that compounding must remain within the limits of South African law and cannot be used for large-scale manufacture, advertising or distribution of unregistered medicines.

Counterfeit or falsified medicine

A counterfeit or falsified medicine is designed to look like a real, authorised medicine, but it may not be made by the genuine manufacturer or supplied through the correct legal channels.

It may contain:

  • the wrong ingredient,
  • too much or too little of an ingredient,
  • no active ingredient,
  • contaminated ingredients,
  • or ingredients that have not been safely manufactured or stored.

Unregistered medicine

An unregistered medicine has not been approved by SAHPRA for sale in South Africa. That means it has not gone through the required local review for quality, safety and effectiveness.

SAHPRA Statement

Warning signs to look out for

Be careful if a medicine is:

  • sold through WhatsApp, Facebook, Instagram, TikTok or an informal website,
  • offered without a prescription,
  • described as a “generic”, “copy”, “compound” or “peptide” version of a prescription weight-loss medicine,
  • much cheaper than expected,
  • supplied as a powder to reconstitute or in packaging that looks unfamiliar,
  • advertised with dramatic before-and-after weight-loss claims,
  • promoted as “SAHPRA approved” without clear proof,
  • sold by a supplier with no physical address or pharmacist contact,
  • delivered from outside South Africa despite local claims,
  • or supplied with spelling errors, broken seals or unusual packaging.

SAHPRA has specifically warned the public about GLP‑1 products sold through social media platforms, including false claims of SAHPRA approval and products shipped from outside South Africa. 

What to do if you are worried about a medicine

1. Do not use it
If the product looks suspicious, do not inject it, swallow it or continue using it.

2. Keep the evidence
Keep the packaging, receipt, batch number, seller details, screenshots and any messages.

3. Speak to a healthcare professional
Take the product to a pharmacist or speak to your doctor. They can help you decide what to do next.

4. Report suspicious products
Report suspicious medicine sales or false claims of SAHPRA approval to SAHPRA. SAHPRA lists a 24-hour hotline: 0800 204 307. SAHPRA whistleblower site: https://www.sahpra.org.za/whistleblower/

5. Get urgent medical help if needed
If you feel unwell after using any medicine — especially an injectable product — seek medical help immediately.

References
  1. World Health Organization. 2024. Substandard and falsified medical products. Fact sheet. Geneva: World Health Organization. Published 3 December 2024. Accessed 29 June 2026. Available at: https://www.who.int/news-room/fact-sheets/detail/substandard-and-falsified-medical-products
  2. South African Health Products Regulatory Authority. n.d. Peptide Products – Public Information. Pretoria: South African Health Products Regulatory Authority. Accessed 29 June 2026. Available at: https://www.sahpra.org.za/peptide-products-public-information/
  3. South African Health Products Regulatory Authority. 2025. SAHPRA warns the public about GLP‑1 products sold through social media platforms. News & Updates / Press Releases. Pretoria: South African Health Products Regulatory Authority. Published 11 November 2025; posted 12 November 2025. Accessed 29 June 2026. Available at: https://www.sahpra.org.za/news-and-updates/sahpra-warns-the-public-about-glp-1-products-sold-through-social-media-platforms/
  4. South African Health Products Regulatory Authority and South African Pharmacy Council. 2026. SAHPRA and the SAPC Crack Down on Unlawful Manufacturing of Unregistered GLP‑1/GIP Medicines. News & Updates / Press Releases. Pretoria: South African Health Products Regulatory Authority. Published 23 May 2026. Accessed 29 June 2026. Available at:https://www.sahpra.org.za/press-releases/sahpra-and-the-sapc-crack-down-on-unlawful-manufacturing-of-unregistered-glp-1-medicines/ 
  5. South African Pharmacy Council. n.d. Pharmacies Overview. Pretoria: South African Pharmacy Council. Accessed 29 June 2026. Available at: https://www.sapc.za.org/Pharmacies_Overview
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ZA26OB00422 | June 2026